Family pedigrees
However, is there an alternative explanation?
Family pedigrees |
|
|---|---|
| “Autosomal recessive” pedigree |
This
pedigree appears to demonstrate an autosomal recessive pattern of inheritance
for 'local' hypoplastic amelogenesis imperfecta. It indicates a recessive
traite because although both siblings in the III generation clinically show the
disease (filled symbols) neither parent does so (open symbols). Therefore, both
parents must be heterozygous, with one normal allele and one affected
allele. However, is there an alternative explanation? |
Characterisation of AD Local Hypoplastic Amelogenesis Imperfecta Phenotype |
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|---|---|
Photograph of Autosomal
Dominant Local Hypoplastic Amelogenesis Imperfecta Affected Deciduous
Tooth and a Longitudinal Section Taken at the Point Indicated by the Red
Line |
The section cuts through a
region of apparently normal enamel on the labial surface and through a
hypoplastic region on the lingual side. Enamel in this region is approximately
50% of that found in control deciduous teeth |